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No more Guttenberg is probably premature as he's likely to be back before long.
After two weeks' kerfuffle about his copy 'n pasting his doctrorate, KT zu Guttenberg wasn't left a lot of options, although Chancellor Merkel seemed happy for him to stay.
But when Professors at your old university start calling you a BetrĂ¼ger (fraud, impostor), when political enemies in your own party are saying how ashamed they are, and the country's tabloids are writing about nothing else, staying on as a minister soon becomes untenable.
If he lies low for a bit and shows a bit of remorse (so ill-suited to his brand before, but necessary now), he'll be well placed to take over in the CSU in Bayern. From there, a bid for the Chancellorship itself is far from unfeasible.
His head-turning popularity among German voters will likely make him think along such lines.